• Basis of process design • Upstream processing – Batch, fed -batch, continuous, perfusion 2 • Downstream processing – Philosophy – Chromatography – Examples • Conclusions. What is a bioprocess? • Application of natural or genetically manipulated ... Process control requirements Scale- up (>100 litre) Process kinetics ...
Upstream Process Development. Each step in an upstream process impacts the quality, purity and quantity of the manufactured protein. At AGC Biologics, we have developed over 80 mammalian, bacteria and yeast based processes in the last decade, giving us the insight necessary to identify and optimize upstream parameters that are critical for achieving a high-quality, cost-effective ...